They may suggest that you dissolve the capecitabine tablets in water. XE or CAP - capecitabine (Xeloda ) OX - oxaliplatin. If your white blood cell count is low, your doctor may delay your treatment for a short time, until your cell count increases. They may give the drug more slowly or flush it through with more fluid to reduce pain. Dont breastfeed during this treatment and for 2 weeks after your final treatment. Isle of Man company number 4694F. This treatment may make your eyes feel sore, red and itchy (conjunctivitis). Less commonly you might also bleed from other areas of the body for other reasons. If your immune system is weak, you need to avoid live vaccinations. They have various thickness/heaviness and those were the ones I used, including sometimes sleeping with them. His Drs says theres no standard line second-line treatment . Very rarely, this can cause heart failure or a heart attack. You can visit the electronic Medicines Compendium (eMC) for more detailed information about your treatment. Randomisation was done . avoid alcohol, tobacco, and foods that irritate your mouth and throat. FOLFIRI Protocol V1.1. The skin may also begin to peel. Oxaliplatin can make you more sensitive to the cold. The symptoms usually improve slowly after treatment finishes. needing to pass urine (pee) a lot, or discomfort when you pass urine. Signs of a severe skin reaction include peeling or blistering of the skin. Talk to your doctor or nurse about effective contraception before starting treatment. For further information about this treatment go to the electronic Medicines Compendium (eMC)website. Each cycle lasts 3 weeks (21 days). It is not a substitute for professional medical advice. Mine will last for 6 months in 12 sessions. I'm one who had relatively mild effects from the Folfox/pump regime, limited to some nueropathy in hands and feet, cold sensitivity in my hands and throat, and fatigue, especially when it was real warm[SoCal area]. Ugh. Each cycle lasts 3 weeks (21 days). The second week I was eating normally. Always take your tablets exactly as explained. Rarely some people might cough up blood or have unusual bleeding from the vagina. Infections can sometimes be life threatening. Men might be able tostore spermbefore starting treatment. Find out about the emotional, physical and practical effects of cancer and how to manage them. I am on oxaliplatin and capecitabine. Gentle exercise, like short walks, can give you more energy. Use a soft toothbrush to clean your teeth or dentures in the morning, at night and after meals. If your immune system is severely weakened, you should avoid contact with children who have had the flu vaccine as a nasal spray as this is a live vaccine. Macmillan Support Line - 0808 808 00 00, 7 days a week between 8am-8pm. I think I would definitely run this past your oncologist as some of the oxaliplatin side effects can get worse even after stopping and its not something that you would want to risk having on a permanent basis. Contact a doctor straight away if you have any of the following symptoms: Read more about treatment for bowel cancer, Find out more about having a DPD deficiency, drop in thenumber ofplatelets in your blood, skin on your hands and feet may become sore, red, or may peel, Read more about how to cope with side effects, Find out more about the COVID-19 vaccine and cancer. Skinproblemsincludea skin rash which might be red and itchy. Are you going to be on Avastin as well? Taste changesmay make you go off certain foods and drinks. Not the same chemo but I had severe pains in my joints all over my body also in my legs and feet. Week off was easier. Talk to your doctor if you are worried about this. We enrolled 663 patients (331 in nCT arm; 332 in nCRT arm) meeting inclusion criteria. They may give you a copy of the treatment plan to take home with you. Never worry about being over cautious and always mention anything that seems out of the ordinary - I mentioned in passing that my tongue felt funny and like Id eaten a whole bag of aniseed balls and the oncologist stopped the oxaliplatin from then on. Tell your doctor or nurse if you keep gettingheadaches. Tell your doctor if you have these symptoms. This side effect can be frightening, but it should only be temporary. But there are various programs which can help with the payments. Signs of a reaction can include: Your nurse will check you for signs of a reaction during your treatment. Oxaliplatin forms crosslinks that inhibit DNA replication and transcription, resulting in cell death in actively dividing cells. Use a good, rich thick lotion. I've gotten the feeling back in my hands (pretty much) but my feet are still a problem. If you feel unwell or need advice, you can call them at any time of the day or night. You might lose your appetite for various reasons whilst having cancer treatment. Tiredness and weakness (fatigue)can happen during and after treatment. If you need medical treatment for any reason other than cancer, always tell the doctors and nurses you are having cancer treatment. Accessed April 2021, Immunisation against infectious disease: Chapter 6: General contraindications to vaccination Reading questions, answers and feedbacks made me feel very comfortable due to my illness with colon cancer stage 3. Affiliation 1 . Avoid close contact with people who have recently had live vaccines taken by mouth (oral vaccines) such as the oral typhoid vaccine. Make sure you drink plenty of fluids during the 24 hours following chemotherapy. Let your nurse know straight away if it's affecting your breathing and swallowing. It helps to keep your mouth and teeth clean, drink plenty of fluids and avoid acidic foods such as lemons. You are advised not to breastfeedwhile having this treatment, or for some time after treatment finishes. This can happen whilst you have oxaliplatin or within a few hours of it finishing. Coping with cancer can be difficult. You may not be able to become pregnant or father a child after treatment with thesedrugs. You usually take the tablets twice a day, about 12 hours apart. We help people get through cancer. Abstract. This can cause symptoms including: Tell your doctor or nurse straight away if you notice any of these symptoms. Oxaliplatin can cause pain at the place where the injection is given or along the vein. Chemotherapy alone - Adjuvant capecitabine plus oxaliplatin (CAPOX) for stage II to III gastric cancer - Capecitabine plus oxaliplatin advanced esophagogastric cancer - Docetaxel, cisplatin, and fluorouracil (DCF) - Modified docetaxel, cisplatin, and fluorouracil (modified DCF) - Epirubicin, cisplatin, and fluorouracil (ECF) - Epirubicin, cisplatin, and . Your hair may get thinner. Actually, I feel pretty good. Worth having a chat . And I am not going to be polite like Tru, STAY OUT OF BED!!! This can make you more likely to get a mouth or throat infection. Arm C received 3 cycles of neoadjuvant SOX and 5 cycles of adjuvant SOX . oxaliplatin and capecitabine (CAPOX) before CRT and TME in pa-tients with poor prognosis rectal cancer in a single-arm phase II trial (EXPERT).30 Patients received four cycles of CAPOX followed by capecitabine CRT, TME, and 12 weeks of adjuvant capecitabine. The week I was on chemo was the time when I dropped a bit of weight, was fortunate not nauseous, but not hungry. You take capecitabine tablets in the morning. Contact with others who have had immunisations-You can be in contact with other people who have had live vaccines as injections. Now I know I have to drink only warm or hot water for a few days after the iv. Hi , Welcome back to the forum . The week on chemo I did get careful with drinking cold things, would bring it to room temperture with small sips. We conducted the first ever randomised trial specific for this rare subgroup (4 regimens). Hair loss usually starts after your first or second treatment. The content on this site is for informational purposes only. Cancer drugs can interact with some other medicines and herbal products. Whetheryou have a full or an empty stomach can affect how much of a drug gets into your bloodstream. Keep them safe and out of sight and reach of children. This treatment can cause back pain and pain at the drip site during treatment. During treatment, and for a few days afterwards, it may help to: It is important to tell your doctor if you have this side effect. I liked being on Xeloda rather than the 5-FU pump. The lab work showed I had Stage 3 cancer with 3 of 27 lymph nodes affected. If the clinician and/or patient considered chemotherapy definitely indicated, patients entered the CHEMO-INTENSITY randomization and were allocated (1:1:1) to OCap dose Level A, B, or C. Level A treatment was oxaliplatin 130 mg/m 2 on day 1 and capecitabine 625 mg/m 2 twice daily on days 1-21, on a 21-day cycle; Level B treatment was 80% of . Based on the gene mutation profile, the patient received the bevacizumab-oxaliplatin regime and then the bevacizumab-capecitabine as maintenance treatment. Capecitabine 14/7 (267 or 400 mg/kg) and 7/7 (467 or 700 mg/kg) schedules in doublet and triplet combinations with optimally dosed bevacizumab (5 mg/kg) and oxaliplatin (6.7 mg/kg) were . FOLFIRINOX. Cycle frequency 21 days Number of cycles Maximum of 8 cycles. If you get a high temperature, let your health care teamknow straight away. The tube stays in place throughout the course of treatment. Your nurse will give you medicines beforehand to try to prevent a reaction. If you are sick just after taking the tablets, contact the hospital. story on my blogentitled "How I Beat Stage Four Colon Cancer" if you would care to read it. Other rare skin changes include ulcers, raised areas of skin that may be itchy, being sensitive to sunlight and previously treated areas of skin with radiation can become irritated and inflamed. It is important to take them exactly as your nurse or pharmacist explains. To meet the growing demand for prescription and non-prescription weight loss products, pharmaceutical companies invest millions of $ in the development and research of new diet pills. Where I live gets really cold in the winter and when I leave the cancer center after the iv if it's really cold I have to cover my nose and mouth to breath when I'm outside, but that usually only lasts a day or two. Ask your doctor or pharmacisthow long you should avoid live vaccinations. The oxilaplatin causes neuropathy and cold sensitivity. I would LIKE this if there were a button. Feeling or being sickis usually well controlled with anti sickness medicines. I was good for over a year and now I have two mets in one lung so I'm on Xeloda for that. It can cause damage. Stay as active as you can for as long as you can. I had it in the winter and it was not fun. Also operating in Northern Ireland. A lot of it may just be luck or makeup, things not in our control, but mindset and determination are also a big part of all of this. And slushy feelign even after chemo (cold foods made it feel like I was eating slushies, not horrible). This treatment may cause you discomfort when you pass urine (pee). I really do hope you find a quick solution . I'd come home from chemo with my fingers tingling, but not really painful. Sometimes people who have had the live shingles vaccine can get a shingles type rash. a short thin tube the nurse puts into a vein in your arm or hand (, a fine tube that goes under the skin of your chest and into a vein close by (, a fine tube that is put into a vein in your arm and goes up into a vein in your chest (. Your doctor or nurse can give you more information. I wish I had said more about it now as I just thought the side effects would disappear in time. court over 3 years ago. Tell your healthcare team if you're finding it difficult to walk or complete fiddly tasks such as doing up buttons. The virus is in the babys poo for about 2 weeks and could make you ill if your immunity is low. April 2017 #1. You should take the right dose, no moreor less. Always tell your cancer doctor about any drugs you are taking or planning to take, such as: Tell other doctors, pharmacists or dentists who prescribe or give you medicines that you are having this cancer treatment. 1,2. avoid tight-fitting socks, shoes and gloves. Wear good fitting shoes and socks to prevent rubbing. ChildrenUse and dose must be determined by your doctor. I kind of wonder if this will go away soon. Patients in both groups received adjuvant chemotherapy (capecitabine or fluorouracil and oxaliplatin) after CRT. If you have pain or notice any change in your vision, always tell your doctor or nurse. It can affect your throat causing it to feel as though it is difficult to breathe and swallow. You have oxaliplatin and capecitabine chemotherapy as cycles of treatment. Sucking sugar-free sweets may help with this. The cancer center I go to changed the way they do it and now I get it over 4 hours and that's much better. Sorry you are here, but a good place and people. The risk of this happening is very low (less than 1 in 100 or 1%). So I went out as much as possible. If the number of red blood cells is low, this is called anaemia. This includes your eyelashes, eyebrows, underarm, leg and sometimes pubic hair. On day of hiccups, one day bad bowel movements. But the team was on the road One of the things that is most important it try not to worry or dwell on this s--t that has been handed to you. If you have breathing difficulties, take long, deep breaths through your nose. Patients were randomly assigned (1:1) to chemotherapy every 3 weeks (intravenous oxaliplatin 130 mg/m 2 on day 1 plus either oral S-1 40 mg/m 2 [SOX] or oral capecitabine 1000 mg/m 2 [CAPOX], twice daily on days 1-14), in addition to either 360 mg nivolumab intravenously every 3 weeks (nivolumab plus chemotherapy group) or placebo (placebo plus chemotherapy group). Depending on your needs, you may have between 4 and 8 cycles. Electronic Medicines Compendium I also have been left with painful feet which I did mention but not until after all my chemo had finished! You should take them within 30 minutes of finishing a meal. Our community is available 24/7 and has dedicated forums where . Mother (66F, colon CA IIIB) is starting her 4th round of XELOX ( capecitabine +oxaliplatin) and has 4 more to go. For colorectal cancer: Your nurse can give you more advice. Put it on hands and feet religiously, morning and night to minimize problems. Our community is available 24/7 and has dedicated forums where you can get advice and ask our experts. Oxaliplatin & Capecitabine. Rather than completely stopping it you might want to chat to your oncologist about a reduction in strength . Your donations make it happen. Or your level of potassium might go down. Contact your advice line, doctor or nurse immediately if you have signs of infection, such as a temperature above 37.5C or below 36C, or if you develop a severe skin reaction. I'm not sure if this is related to the Capecitabine or the Oxaliplatin that I get via infusion every 3 weeks. You might want to hurry and get a few pairs of those stretchy knit gloves that are one size fits all. I love to be active so I will try to stay out of bed as much as possible. Your doctor or nurse will talk to you about this. If it is something where you can say screw it and deal with it later, that could be easier. I actually responded well to avastin. 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